Where can you fly direct from Panama City?

Currently, the most popular direct flight destination from Panama City is Managua.

How much are direct flights from Panama City?

On average, a one-way direct flight from Panama City will cost users approximately $589. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around $568.

What is the best time of year to fly direct from Panama City?

If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest

Last-minute

One-way

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 2 February 2026.

Thu 19/216:00

PTY

CLO

Nonstop1h 50m

Copa Airlines

Wed 25/208:48

CLO

PTY

Nonstop1h 32m

Copa Airlines

Deal found 1/2$350

Fri 27/211:33

PTY

SAL

Nonstop2h 10m

Copa Airlines

Tue 17/313:45

SAL

PTY

Nonstop2h 07m

Copa Airlines

Deal found 31/1$408

Fri 13/212:29

PTY

CLO

Nonstop1h 41m

Copa Airlines

Fri 20/208:48

CLO

PTY

Nonstop1h 32m

Copa Airlines

Deal found 2/2$411

Wed 15/409:25

PTY

CLO

Nonstop1h 41m

Copa Airlines

Fri 15/515:10

CLO

PTY

Nonstop1h 34m

Copa Airlines

Deal found 2/2$412

Sat 14/216:00

PTY

CLO

Nonstop1h 50m

Copa Airlines

Tue 17/215:11

CLO

PTY

Nonstop1h 33m

Copa Airlines

Deal found 1/2$456

Sat 9/509:25

PTY

CLO

Nonstop1h 41m

Copa Airlines

Mon 11/508:46

CLO

PTY

Nonstop1h 34m

Copa Airlines

Deal found 1/2$471

Fri 5/609:25

PTY

CLO

Nonstop1h 41m

Copa Airlines

Wed 10/612:06

CLO

PTY

Nonstop1h 34m

Copa Airlines

Deal found 1/2$487

Sat 4/712:30

PTY

CLO

Nonstop1h 40m

Copa Airlines

Fri 10/708:46

CLO

PTY

Nonstop1h 34m

Copa Airlines

Deal found 1/2$502

Fri 13/216:00

PTY

CLO

Nonstop1h 50m

Copa Airlines

Wed 18/205:03

CLO

PTY

Nonstop1h 31m

Copa Airlines

Deal found 1/2$515

Sun 1/312:29

PTY

CLO

Nonstop1h 40m

Copa Airlines

Sun 29/308:46

CLO

PTY

Nonstop1h 34m

Copa Airlines

Deal found 31/1$818

Fly to

Route

Depart

Return

Price

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 19/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Sun 22/2

05:03-06:34

Nonstop1h 31m

$350

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 9/4

09:25-11:06

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Tue 14/4

15:10-16:44

Nonstop1h 34m

$350

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 2/3

12:29-14:09

Nonstop1h 40m

Cali Alfonso B. Aragon Intl

Wed 4/3

08:48-10:20

Nonstop1h 32m

$350

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 19/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Wed 25/2

05:03-06:34

Nonstop1h 31m

$350

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 27/2

12:29-14:10

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Mon 2/3

15:11-16:44

Nonstop1h 33m

$350

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 10/4

15:55-17:36

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Sun 12/4

12:06-13:40

Nonstop1h 34m

$350

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 25/6

22:28-23:37

Nonstop2h 09m

San Salvador El Salvador Intl

Mon 29/6

04:53-08:05

Nonstop2h 12m

$408

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 27/2

11:33-12:43

Nonstop2h 10m

San Salvador El Salvador Intl

Tue 17/3

13:45-16:52

Nonstop2h 07m

$408

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Tue 3/3

21:55-23:34

Nonstop1h 39m

$187

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 24/4

09:25-11:06

Nonstop1h 41m

$187

Flights are sorted by cheapest return flights first.

Deals found on 31/1

Showing 1-10 of 18 results

Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.

PTY-MEL

PTY-CLO

PTY-SAL

Estimated return price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Where can you fly direct from Panama City?
Currently, the most popular direct flight destination from Panama City is Managua.
How much are direct flights from Panama City?
On average, a one-way direct flight from Panama City will cost users approximately $589. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around $568.
What is the best time of year to fly direct from Panama City?
If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

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This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.