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$176+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 14/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — SYD
4 Apr — 11 Apr1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 5 March 2026.

Thu 2/422:28
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 5/404:57
SAL
-
PTY
Nonstop2h 08m
Copa Airlines
Deal found 3/3$331
Thu 30/419:25
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 3/504:53
SAL
-
PTY
Nonstop2h 12m
Copa Airlines
Deal found 2/3$389
Fri 1/511:33
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 3/504:53
SAL
-
PTY
Nonstop2h 12m
Copa Airlines
Deal found 2/3$403
Fri 3/412:29
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Mon 13/405:00
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 1/3$447
Thu 30/409:25
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Sun 31/515:10
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 2/3$449
Fri 19/612:29
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Sat 4/712:06
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 1/3$463
Fri 20/309:25
PTY
-
CLO
Nonstop1h 39m
Copa Airlines
Fri 27/318:31
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 4/3$477
Wed 29/412:29
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Tue 5/515:10
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 4/3$478
Mon 23/309:25
PTY
-
CLO
Nonstop1h 39m
Copa Airlines
Mon 23/315:11
CLO
-
PTY
Nonstop1h 33m
Copa Airlines
Deal found 1/3$501
Fri 27/309:25
PTY
-
CLO
Nonstop1h 39m
Copa Airlines
Sun 29/308:46
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 4/3$531
Wed 18/319:25
PTY
-
SAL
Nonstop2h 14m
Copa Airlines
Fri 27/305:02
SAL
-
PTY
Nonstop2h 09m
Copa Airlines
Deal found 2/3$539
Tue 24/311:33
PTY
-
SAL
Nonstop2h 10m
Copa Airlines
Sat 28/305:02
SAL
-
PTY
Nonstop2h 09m
Copa Airlines
Deal found 1/3$639

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 647,157 searches. This data was last updated on 5 March 2026.

Fly to

Route

Depart

Return

Price

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Wed 6/5

11:33-12:41

Nonstop2h 08m

San Salvador El Salvador Intl

Fri 15/5

13:58-17:10

Nonstop2h 12m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 3/4

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Fri 10/4

08:33-11:38

Nonstop2h 05m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 30/4

19:25-20:33

Nonstop2h 08m

San Salvador El Salvador Intl

Mon 11/5

07:30-10:42

Nonstop2h 12m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 16/5

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Mon 18/5

13:58-17:10

Nonstop2h 12m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Tue 2/6

19:25-20:34

Nonstop2h 09m

San Salvador El Salvador Intl

Sat 6/6

13:58-17:10

Nonstop2h 12m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Mon 30/3

22:28-23:35

Nonstop2h 07m

San Salvador El Salvador Intl

Thu 2/4

07:30-10:35

Nonstop2h 05m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 20/3

19:25-20:39

Nonstop2h 14m

San Salvador El Salvador Intl

Mon 23/3

05:02-08:11

Nonstop2h 09m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 13/8

19:25-20:31

Nonstop2h 06m

San Salvador El Salvador Intl

Wed 19/8

13:59-17:10

Nonstop2h 11m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sun 19/4

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Thu 23/4

04:57-08:05

Nonstop2h 08m

$331

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 9/4

19:25-20:33

Nonstop2h 08m

San Salvador El Salvador Intl

Tue 14/4

14:02-17:10

Nonstop2h 08m

$331

Flights are sorted by cheapest return flights first.

Deals found on 4/3

Showing 1-10 of 40 resultsSorted by cheapest first
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 5 March 2026.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Medellín Jose Maria Cordova Intl Airport.

  • How much are direct flights from Panama City?

    On average, a one-way direct flight from Panama City will cost users approximately $375. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around $561.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

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