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$220+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 19/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — MEL
15 Feb — 22 Feb1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 16 January 2026.

Mon 9/212:29
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Fri 13/208:48
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 14/1$405
Tue 3/221:55
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Tue 10/208:48
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 16/1$415
Sun 12/422:28
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 19/414:02
SAL
-
PTY
Nonstop2h 08m
Copa Airlines
Deal found 15/1$424
Mon 26/109:20
PTY
-
CLO
Nonstop1h 40m
Copa Airlines
Sun 1/208:48
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 14/1$447
Fri 20/321:55
PTY
-
CLO
Nonstop1h 39m
Copa Airlines
Fri 27/312:02
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 16/1$453
Fri 13/221:55
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Wed 18/205:03
CLO
-
PTY
Nonstop1h 31m
Copa Airlines
Deal found 14/1$474
Wed 11/216:00
PTY
-
CLO
Nonstop1h 50m
Copa Airlines
Tue 17/205:03
CLO
-
PTY
Nonstop1h 31m
Copa Airlines
Deal found 16/1$484
Sat 14/221:55
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Wed 18/208:48
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 14/1$542
Wed 18/209:25
PTY
-
CLO
Nonstop1h 40m
Copa Airlines
Wed 18/215:11
CLO
-
PTY
Nonstop1h 33m
Copa Airlines
Deal found 14/1$673
Tue 30/621:55
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Tue 7/705:00
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 14/1$680
Sat 14/219:25
PTY
-
SAL
Nonstop2h 14m
Copa Airlines
Mon 16/213:45
SAL
-
PTY
Nonstop2h 07m
Copa Airlines
Deal found 14/1$761

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 647,157 searches. This data was last updated on 16 January 2026.

Fly to

Melbourne

Route

Depart

Return

Price

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 16/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Sun 1/3

15:11-16:44

Nonstop1h 33m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 6/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Mon 9/2

15:11-16:44

Nonstop1h 33m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Sun 22/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Sun 1/3

05:03-06:34

Nonstop1h 31m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 9/4

09:25-11:06

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Tue 14/4

05:00-06:34

Nonstop1h 34m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 2/2

12:29-14:10

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Thu 5/2

15:11-16:44

Nonstop1h 33m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 19/2

09:25-11:05

Nonstop1h 40m

Cali Alfonso B. Aragon Intl

Wed 25/2

05:03-06:34

Nonstop1h 31m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 20/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Mon 23/2

08:48-10:20

Nonstop1h 32m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Tue 17/2

12:29-14:10

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Fri 27/2

15:11-16:44

Nonstop1h 33m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 13/2

21:55-23:36

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Fri 20/2

05:03-06:34

Nonstop1h 31m

$405

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 10/4

09:25-11:06

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Sun 12/4

05:00-06:34

Nonstop1h 34m

$405

Flights are sorted by cheapest return flights first.

Deals found on 13/1

Showing 1-10 of 32 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 16 January 2026.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Managua.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

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