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$196+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 23/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — MEL
19 Mar — 26 Mar1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 17 February 2026.

Mon 16/315:50
PTY
-
SAL
Nonstop2h 00m
Avianca
Wed 18/315:45
SAL
-
PTY
Nonstop2h 10m
Avianca
Deal found 15/2$328
Thu 12/311:33
PTY
-
SAL
Nonstop2h 10m
Copa Airlines
Mon 16/313:45
SAL
-
PTY
Nonstop2h 07m
Copa Airlines
Deal found 14/2$371
Wed 1/411:33
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 5/408:33
SAL
-
PTY
Nonstop2h 05m
Copa Airlines
Deal found 14/2$386
Sun 28/611:33
PTY
-
SAL
Nonstop2h 09m
Copa Airlines
Mon 10/813:59
SAL
-
PTY
Nonstop2h 11m
Copa Airlines
Deal found 13/2$401
Mon 2/312:29
PTY
-
CLO
Nonstop1h 40m
Copa Airlines
Thu 5/312:02
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 16/2$414
Sat 9/512:29
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Mon 11/512:06
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 13/2$415
Sat 20/612:29
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Wed 24/612:06
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 13/2$431
Sun 15/321:55
PTY
-
CLO
Nonstop1h 39m
Copa Airlines
Tue 24/312:02
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 15/2$453
Thu 2/411:33
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 5/408:33
SAL
-
PTY
Nonstop2h 08m
Copa Airlines
Deal found 17/2$462
Mon 23/309:25
PTY
-
CLO
Nonstop1h 39m
Copa Airlines
Sun 29/312:08
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 15/2$469
Fri 20/321:55
PTY
-
CLO
Nonstop1h 39m
Copa Airlines
Fri 27/312:02
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 14/2$507
Sun 1/316:00
PTY
-
CLO
Nonstop1h 49m
Copa Airlines
Sun 29/312:08
CLO
-
PTY
Nonstop1h 32m
Copa Airlines
Deal found 14/2$554

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 647,157 searches. This data was last updated on 17 February 2026.

Fly to

Melbourne

Route

Depart

Return

Price

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Mon 16/3

15:50-16:50

Nonstop2h 00m

San Salvador El Salvador Intl

Wed 18/3

15:45-18:55

Nonstop2h 10m

$328

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Mon 4/5

05:30-06:30

Nonstop2h 00m

San Salvador El Salvador Intl

Sun 24/5

07:30-10:30

Nonstop2h 00m

$328

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Wed 18/3

19:50-20:55

Nonstop2h 05m

San Salvador El Salvador Intl

Wed 25/3

07:30-10:30

Nonstop2h 00m

$328

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Tue 7/4

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Tue 21/4

08:33-11:38

Nonstop2h 05m

$371

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 12/3

11:33-12:43

Nonstop2h 10m

San Salvador El Salvador Intl

Mon 16/3

13:45-16:52

Nonstop2h 07m

$371

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 28/3

22:28-23:37

Nonstop2h 09m

San Salvador El Salvador Intl

Sun 5/4

04:57-08:05

Nonstop2h 08m

$371

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 1/5

11:33-12:41

Nonstop2h 08m

San Salvador El Salvador Intl

Mon 11/5

07:30-10:42

Nonstop2h 12m

$371

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Wed 1/4

11:33-12:41

Nonstop2h 08m

San Salvador El Salvador Intl

Sun 5/4

08:33-11:38

Nonstop2h 05m

$386

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sun 28/6

11:33-12:42

Nonstop2h 09m

San Salvador El Salvador Intl

Mon 10/8

13:59-17:10

Nonstop2h 11m

$401

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Tue 17/3

11:33-12:43

Nonstop2h 10m

San Salvador El Salvador Intl

Tue 24/3

08:35-11:41

Nonstop2h 06m

$401

Flights are sorted by cheapest return flights first.

Deals found on 14/2

Showing 1-10 of 27 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 17 February 2026.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Medellín Jose Maria Cordova Intl Airport.

  • How much are direct flights from Panama City?

    On average, a one-way direct flight from Panama City will cost users approximately $373. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around $558.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

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