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$207+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — MEL
8 Feb — 15 Feb1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 9 January 2026.

Tue 17/216:00PTY - CLO
Nonstop1h 50mCopa Airlines
Thu 5/305:03CLO - PTY
Nonstop1h 31mCopa Airlines
Deal found 8/1$404
Thu 2/411:33PTY - SAL
Nonstop2h 08mCopa Airlines
Sun 5/414:02SAL - PTY
Nonstop2h 08mCopa Airlines
Deal found 7/1$424
Fri 13/216:00PTY - CLO
Nonstop1h 50mCopa Airlines
Sun 22/215:11CLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 6/1$446
Wed 25/219:50PTY - SAL
Nonstop2h 05mAvianca
Fri 13/315:45SAL - PTY
Nonstop2h 10mAvianca
Deal found 7/1$455
Sun 15/321:55PTY - CLO
Nonstop1h 39mCopa Airlines
Tue 24/315:11CLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 7/1$463
Sun 1/316:00PTY - CLO
Nonstop1h 49mCopa Airlines
Sun 29/308:46CLO - PTY
Nonstop1h 34mCopa Airlines
Deal found 7/1$563
Fri 13/211:33PTY - SAL
Nonstop2h 10mCopa Airlines
Tue 17/208:35SAL - PTY
Nonstop2h 06mCopa Airlines
Deal found 7/1$584
Fri 20/309:25PTY - CLO
Nonstop1h 39mCopa Airlines
Fri 27/312:02CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 8/1$872

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 647,157 searches. This data was last updated on 9 January 2026.

Fly to

Melbourne

Route

Depart

Return

Price

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 19/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Wed 25/2

15:11-16:44

Nonstop1h 33m

$404

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Tue 17/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Thu 5/3

05:03-06:34

Nonstop1h 31m

$404

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 22/1

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Wed 28/1

14:04-17:10

Nonstop2h 06m

$424

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Wed 1/4

11:33-12:41

Nonstop2h 08m

San Salvador El Salvador Intl

Sun 5/4

04:57-08:05

Nonstop2h 08m

$424

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Tue 20/1

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Tue 27/1

08:36-11:41

Nonstop2h 05m

$424

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sun 12/4

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Sun 19/4

08:33-11:41

Nonstop2h 08m

$424

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Mon 16/3

19:25-20:39

Nonstop2h 14m

San Salvador El Salvador Intl

Mon 23/3

13:45-16:52

Nonstop2h 07m

$424

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 13/3

22:28-23:37

Nonstop2h 09m

San Salvador El Salvador Intl

Mon 16/3

13:45-16:52

Nonstop2h 07m

$424

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Wed 11/3

22:28-23:37

Nonstop2h 09m

San Salvador El Salvador Intl

Sun 15/3

08:35-11:41

Nonstop2h 06m

$424

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sun 28/6

11:33-12:42

Nonstop2h 09m

San Salvador El Salvador Intl

Mon 10/8

04:54-08:05

Nonstop2h 11m

$424

Flights are sorted by cheapest return flights first.

Deals found on 7/1

Showing 1-10 of 32 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 9 January 2026.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Managua.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

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