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$225+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 24/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — MEL
4 Jan — 11 Jan1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 5 December 2025.

Tue 10/216:00PTY - CLO
Nonstop1h 50mCopa Airlines
Fri 13/215:11CLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 2/12$368
Fri 26/1215:50PTY - SAL
Nonstop2h 00mAvianca
Mon 5/115:45SAL - PTY
Nonstop2h 10mAvianca
Deal found 3/12$401
Sun 8/216:00PTY - CLO
Nonstop1h 50mCopa Airlines
Sun 8/305:03CLO - PTY
Nonstop1h 31mCopa Airlines
Deal found 2/12$426
Fri 2/122:28PTY - SAL
Nonstop2h 08mCopa Airlines
Sun 11/105:03SAL - PTY
Nonstop2h 08mCopa Airlines
Deal found 4/12$430
Fri 13/216:00PTY - CLO
Nonstop1h 50mCopa Airlines
Sun 15/215:11CLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 4/12$452
Mon 29/1209:20PTY - CLO
Nonstop1h 41mCopa Airlines
Sun 18/108:48CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 3/12$469
Mon 29/1209:20PTY - CLO
Nonstop1h 41mCopa Airlines
Thu 15/108:48CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 4/12$484
Wed 17/1215:55PTY - CLO
Nonstop1h 42mCopa Airlines
Wed 14/108:48CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 4/12$498
Tue 16/1215:47PTY - CLO
Nonstop1h 42mCopa Airlines
Thu 25/1215:11CLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 2/12$514
Wed 31/1221:55PTY - CLO
Nonstop1h 42mCopa Airlines
Wed 7/105:03CLO - PTY
Nonstop1h 31mCopa Airlines
Deal found 2/12$541
Mon 22/1209:20PTY - CLO
Nonstop1h 41mCopa Airlines
Tue 13/115:11CLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 3/12$543
Sun 14/1215:55PTY - CLO
Nonstop1h 42mCopa Airlines
Fri 20/205:03CLO - PTY
Nonstop1h 31mCopa Airlines
Deal found 4/12$546

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 647,157 searches. This data was last updated on 5 December 2025.

Fly to

Melbourne

Route

Depart

Return

Price

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 23/3

09:25-11:04

Nonstop1h 39m

Cali Alfonso B. Aragon Intl

Mon 23/3

15:11-16:44

Nonstop1h 33m

$368

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Tue 10/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Fri 13/2

15:11-16:44

Nonstop1h 33m

$368

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 6/2

19:50-20:55

Nonstop2h 05m

San Salvador El Salvador Intl

Fri 20/2

15:45-18:55

Nonstop2h 10m

$401

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Sun 8/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Sun 8/3

05:03-06:34

Nonstop1h 31m

$426

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 1/1

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Thu 8/1

14:04-17:10

Nonstop2h 06m

$430

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 2/1

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Sun 11/1

05:03-08:11

Nonstop2h 08m

$430

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 10/1

22:28-23:36

Nonstop2h 08m

San Salvador El Salvador Intl

Sat 31/1

14:04-17:10

Nonstop2h 06m

$430

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 8/1

19:25-20:38

Nonstop2h 13m

San Salvador El Salvador Intl

Sun 11/1

08:36-11:41

Nonstop2h 05m

$430

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 15/1

19:25-20:38

Nonstop2h 13m

San Salvador El Salvador Intl

Thu 22/1

14:04-17:10

Nonstop2h 06m

$430

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 3/1

11:33-12:41

Nonstop2h 08m

San Salvador El Salvador Intl

Sat 10/1

07:30-10:35

Nonstop2h 05m

$430

Flights are sorted by cheapest return flights first.

Deals found on 4/12

Showing 1-10 of 35 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 5 December 2025.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Managua.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, October offers travelers the most options.

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