Where can you fly direct from Panama City?

Currently, the most popular direct flight destination from Panama City is Sao Paulo Guarulhos Intl Airport.

How much are direct flights from Panama City?

On average, a one-way direct flight from Panama City will cost users approximately $1,084. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around $471.

What is the best time of year to fly direct from Panama City?

If you're seeking the lowest price on a direct flight from Panama City, November is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, May offers travelers the most options.

Direct flights from Panama City

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 17 April 2025.

Fri 16/519:10PTY - SAL

Nonstop2h 13mCopa Airlines

Sun 18/513:40SAL - PTY

Nonstop2h 11mCopa Airlines

Deal found 16/4$311

Mon 6/1020:10PTY - SAL

Nonstop1h 55mAvianca

Sun 19/1007:30SAL - PTY

Nonstop1h 55mAvianca

Deal found 16/4$350

Wed 30/412:43PTY - CLO

Nonstop1h 39mCopa Airlines

Sun 4/508:47CLO - PTY

Nonstop1h 33mCopa Airlines

Deal found 17/4$420

Find direct flights from Panama City within your budget

Fly to

Route

Depart

Return

Price

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 16/5

19:10-20:23

Nonstop2h 13m

San Salvador El Salvador Intl

Sun 18/5

13:40-16:51

Nonstop2h 11m

$311

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Mon 6/10

20:10-21:05

Nonstop1h 55m

San Salvador El Salvador Intl

Sun 19/10

07:30-10:25

Nonstop1h 55m

$350

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Wed 30/4

12:43-14:22

Nonstop1h 39m

Cali Alfonso B. Aragon Intl

Sun 4/5

08:47-10:20

Nonstop1h 33m

$420

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Tue 22/4

22:28-23:36

Nonstop2h 08m

$190

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Wed 23/4

09:20-10:59

Nonstop1h 39m

$228

Flights are sorted by cheapest return flights first.

Deals found on 17/4

Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.

Estimated return price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Where can you fly direct from Panama City?
Currently, the most popular direct flight destination from Panama City is Sao Paulo Guarulhos Intl Airport.
How much are direct flights from Panama City?
On average, a one-way direct flight from Panama City will cost users approximately $1,084. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around $471.
What is the best time of year to fly direct from Panama City?
If you're seeking the lowest price on a direct flight from Panama City, November is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, May offers travelers the most options.

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This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.