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$225+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — MEL
16 Jan — 23 Jan1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 17 December 2025.

Sat 23/515:40PTY - SAL
Nonstop1h 55mAvianca
Mon 25/511:50SAL - PTY
Nonstop1h 55mAvianca
Deal found 16/12$398
Sat 31/119:50PTY - SAL
Nonstop2h 05mAvianca
Sun 1/215:45SAL - PTY
Nonstop2h 10mAvianca
Deal found 15/12$401
Fri 13/219:25PTY - SAL
Nonstop2h 14mCopa Airlines
Sun 15/208:35SAL - PTY
Nonstop2h 06mCopa Airlines
Deal found 14/12$428
Wed 31/1221:55PTY - CLO
Nonstop1h 42mCopa Airlines
Thu 15/112:03CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 15/12$451
Mon 29/1212:29PTY - CLO
Nonstop1h 42mCopa Airlines
Tue 6/112:03CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 16/12$467
Sat 27/1209:20PTY - CLO
Nonstop1h 41mCopa Airlines
Tue 20/108:48CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 15/12$482
Wed 31/1222:28PTY - SAL
Nonstop2h 11mCopa Airlines
Fri 2/108:36SAL - PTY
Nonstop2h 05mCopa Airlines
Deal found 17/12$493
Wed 31/1221:55PTY - CLO
Nonstop1h 42mCopa Airlines
Sun 11/108:48CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 16/12$496
Sat 27/1221:55PTY - CLO
Nonstop1h 42mCopa Airlines
Fri 9/112:03CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 16/12$512
Sun 15/212:29PTY - CLO
Nonstop1h 41mCopa Airlines
Tue 10/315:11CLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 16/12$523
Wed 11/209:25PTY - CLO
Nonstop1h 40mCopa Airlines
Tue 17/208:48CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 15/12$539
Sat 27/1209:20PTY - CLO
Nonstop1h 41mCopa Airlines
Mon 12/108:48CLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 16/12$541

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 647,157 searches. This data was last updated on 17 December 2025.

Fly to

Melbourne

Route

Depart

Return

Price

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 23/5

15:40-16:35

Nonstop1h 55m

San Salvador El Salvador Intl

Mon 25/5

11:50-14:45

Nonstop1h 55m

$398

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 7/2

15:50-16:50

Nonstop2h 00m

San Salvador El Salvador Intl

Sun 8/2

07:30-10:30

Nonstop2h 00m

$401

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 31/1

19:50-20:55

Nonstop2h 05m

San Salvador El Salvador Intl

Sun 1/2

15:45-18:55

Nonstop2h 10m

$401

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 14/2

22:28-23:37

Nonstop2h 09m

San Salvador El Salvador Intl

Tue 17/2

08:35-11:41

Nonstop2h 06m

$428

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Sat 14/2

19:25-20:39

Nonstop2h 14m

San Salvador El Salvador Intl

Mon 16/2

07:30-10:36

Nonstop2h 06m

$428

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Fri 13/2

11:33-12:43

Nonstop2h 10m

San Salvador El Salvador Intl

Tue 17/2

08:35-11:41

Nonstop2h 06m

$428

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 1/1

19:25-20:38

Nonstop2h 13m

San Salvador El Salvador Intl

Thu 8/1

07:30-10:35

Nonstop2h 05m

$428

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Wed 11/2

22:28-23:37

Nonstop2h 09m

San Salvador El Salvador Intl

Sun 15/2

05:02-08:11

Nonstop2h 09m

$428

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 13/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Mon 16/2

05:03-06:34

Nonstop1h 31m

$451

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Wed 14/1

09:20-11:00

Nonstop1h 40m

Cali Alfonso B. Aragon Intl

Wed 21/1

12:03-13:35

Nonstop1h 32m

$451

Flights are sorted by cheapest return flights first.

Deals found on 15/12

Showing 1-10 of 36 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 17 December 2025.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Managua.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, October offers travelers the most options.

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