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$177+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — MEL
10 Mar — 17 Mar1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 8 February 2026.

Thu 5/319:50
PTY
-
SAL
Nonstop2h 05m
Avianca
Sun 8/315:45
SAL
-
PTY
Nonstop2h 10m
Avianca
Deal found 7/2$305
Thu 19/216:00
PTY
-
CLO
Nonstop1h 50m
Copa Airlines
Wed 25/205:03
CLO
-
PTY
Nonstop1h 31m
Copa Airlines
Deal found 5/2$348
Wed 1/411:33
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 5/408:33
SAL
-
PTY
Nonstop2h 08m
Copa Airlines
Deal found 7/2$378
Tue 7/411:33
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Tue 21/404:57
SAL
-
PTY
Nonstop2h 08m
Copa Airlines
Deal found 7/2$390
Fri 27/222:28
PTY
-
SAL
Nonstop2h 09m
Copa Airlines
Tue 17/305:02
SAL
-
PTY
Nonstop2h 09m
Copa Airlines
Deal found 6/2$405
Wed 15/409:25
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Fri 15/515:10
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 5/2$409
Thu 2/422:28
PTY
-
SAL
Nonstop2h 08m
Copa Airlines
Sun 5/408:33
SAL
-
PTY
Nonstop2h 08m
Copa Airlines
Deal found 6/2$452
Fri 20/212:29
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Sun 22/205:03
CLO
-
PTY
Nonstop1h 31m
Copa Airlines
Deal found 6/2$466
Fri 24/715:55
PTY
-
CLO
Nonstop1h 40m
Copa Airlines
Fri 31/708:46
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 8/2$467
Wed 3/615:55
PTY
-
CLO
Nonstop1h 41m
Copa Airlines
Wed 10/615:10
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 8/2$483
Mon 16/322:28
PTY
-
SAL
Nonstop2h 09m
Copa Airlines
Sat 28/313:45
SAL
-
PTY
Nonstop2h 07m
Copa Airlines
Deal found 7/2$483
Wed 1/709:26
PTY
-
CLO
Nonstop1h 40m
Copa Airlines
Mon 6/712:06
CLO
-
PTY
Nonstop1h 34m
Copa Airlines
Deal found 5/2$499

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 647,157 searches. This data was last updated on 8 February 2026.

Fly to

Melbourne

Route

Depart

Return

Price

Panama CitySan Salvador

PTY - SAL

PTYSAL

Panama City Tocumen Intl

Thu 5/3

19:50-20:55

Nonstop2h 05m

San Salvador El Salvador Intl

Sun 8/3

15:45-18:55

Nonstop2h 10m

$305

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 9/4

12:29-14:10

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Tue 14/4

15:10-16:44

Nonstop1h 34m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 19/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Wed 25/2

05:03-06:34

Nonstop1h 31m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 5/3

12:29-14:09

Nonstop1h 40m

Cali Alfonso B. Aragon Intl

Thu 12/3

08:48-10:20

Nonstop1h 32m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Sat 28/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Fri 13/3

05:03-06:34

Nonstop1h 31m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 20/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Fri 13/3

08:48-10:20

Nonstop1h 32m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 10/4

15:55-17:36

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Sun 12/4

08:46-10:20

Nonstop1h 34m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 23/2

16:00-17:50

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Mon 2/3

12:02-13:34

Nonstop1h 32m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 13/3

16:00-17:49

Nonstop1h 49m

Cali Alfonso B. Aragon Intl

Tue 17/3

08:48-10:20

Nonstop1h 32m

$348

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 27/3

09:25-11:04

Nonstop1h 39m

Cali Alfonso B. Aragon Intl

Mon 30/3

05:03-06:34

Nonstop1h 31m

$348

Flights are sorted by cheapest return flights first.

Deals found on 6/2

Showing 1-10 of 41 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 8 February 2026.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Medellín Jose Maria Cordova Intl Airport.

  • How much are direct flights from Panama City?

    On average, a one-way direct flight from Panama City will cost users approximately $377. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around $563.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

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